Proteomics

Cancer type is determined via assessment of tumour morphology, aided by immunohistochemical staining patterns. The development of machine learning (ML) models using histology slides has powered the image-based prediction of the site of origin in cancer of unknown primary (CUP).

Proteomic data are a uniquely valuable resource for drug response prediction and biomarker discovery because most drugs interact …

Proteomic data can reveal novel associations between genotype and phenotype, beyond what is apparent from genomics or transcriptomics alone. However, a lack of large proteomic datasets across a range of cancer types has limited our understanding of proteome network organisation and regulation.