Multi-omic integration

Integrative analysis of multi-omic datasets remains a challenge due to gaps and heterogeneity. We present a bespoke unsupervised deep learning model that generates synthetic multi-omic data for 1,523 cancer cell lines, completing the gaps and increasing the number of molecular and phenotypic profiles by 32.

Multi-omic data analysis incorporating machine learning has the potential to significantly improve cancer diagnosis and prognosis. Traditional machine learning methods are usually limited to omic measurements, omitting existing domain knowledge, such as the biological networks that link molecular entities in various omic data types.